Usually straightforward
Radio side: usually some sort of back-panel line-level in and out
Avoid: mic/external speaker into analog soundcard
Either within actual mic port or pair of 3.5mm jacks
Level issues, tone issues, etc.
Yes, you really need to use those DIN ports…
Very basic radio (VHF/UHF): might be only option
Better: separate audio inputs via back-panel
Line-level (not mic/speaker level)
Fixed-volume in and out (not changed by knobs)
Ideally dedicated audio path (no DSP, bandpass, etc.)
Watch out! Sometimes just rerouted mic/speaker…
Best: Dedicated data-specific port
Everything you need – and radio expects
Recent radios: 6-pin mini-DIN (same as PS/2 keyboard/mouse: good for DIY cables!)
And of course, USB…
Pay attention to unexpected differences on certain radios!
Radio may need to be in specific mode (DATA-L/DATA-U vs LSB/USB)
Back-panel audio must use back-panel PTT
Back-panel audio can't use PTT at all – must use radio VOX!
Lots of ways to make a subtle mistake: read your manual! Multiple times!
PC side much easier: practically always sound card
Avoid: using main/internal sound card!
Basic: External generic USB sound card with serial/command PTT (or DIY VOX PTT)
USB radios already have this!
Otherwise: $5 USB sound card with in and out from AdaFruit! ($8 next-day from Amazon)
Protip: Rename those sound card inputs! (“USB Audio” doesn't help…)
Good: External radio USB sound card
Look for VOX PTT capability – highly recommended
Likely easier to connect to radio
Possibly with front-mounted audio controls
Great: Combined external radio USB sound card and radio management interface
Likely easiest connection to both PC and radio
Can make serial-based PTT more streamlined and manageable
Look for same features as Even Better above: VOX, front-mounted control
Differentiators: much more variation
Fixed for a particular radio or reconfigurable for others
USB Sound card built-in
Physical front-panel controls
Multiple audio paths/routing (headphones, external speakers, computer audio, etc.)
Integrated radio management
PTT options